Led by Imperial College London
The APOE4 gene is one of the biggest risk factors for developing Alzheimer’s disease. We want your input in developing a counselling tool for people who choose to get tested for this gene.
Understanding the APOE4 gene
Everyone has two copies of the APOE gene, inherited from each parent. This gene helps support brain, heart, and immune system health. There are three versions of the gene – APOE2, APOE3 and APOE4.
Having one copy of APOE4 increases the risk of developing Alzheimer’s disease, while having two copies increases the risk even more.
Why test for APOE4?
Until recently, testing for APOE4 in healthy people was discouraged. Carrying the gene doesn’t mean you’ll definitely get Alzheimer’s, and there were few effective ways to prevent it.
Now, this is changing. New treatments for early Alzheimer’s are emerging, and we have stronger evidence about how to lower the risk of the disease.
About our project
Researchers at the University of Oxford and Imperial College London are developing a counselling tool to help people understand APOE4 test results. We want to make sure the information is clear, respectful, and relevant — and that’s why your input matters.
Taking part in the survey
We want to hear your thoughts about genetic testing for the APOE4 gene. The survey asks about your motivations, any concerns you might have, and how you’d like this information shared.
Your answers will help us design the best possible counselling support for everyone learning about their APOE4 results. You do not need to have had previous genetic tests yourself.
Who can take part?
We are inviting:
- Individuals with Alzheimer’s disease or other dementias
- Their families and carers
- Professionals working with people with Alzheimer’s disease or other dementias
- Anyone else with a perspective to share
Your perspective will help us create better, more accessible information about the APOE4 gene.
